反应详情

温度

-20 °C

To a solution of DIPA (22.3 mL) in THF (150 mL) was added at −20° C., n-BuLi (2.3M, 63.7 mL, 159 mmol). The mixture was stirred at −20° C. for 10 min. After cooling to −78° C., a solution of 2-chloro-6-fluoro-3-methoxy-quinoxaline (27.1 g, 127.4 mmol) in THF (100 mL+10 mL rinse) was added over 40 min. The reddish mixture was stirred at −78° C. for 40 min. DMF (15 mL) was added keeping the internal temperature below −70° C. The reaction proceeded 20 min. AcOH (15 mL) was added. Once the mixture had warmed up to rt, 3M HCl (180 mL) and EA (500 mL) were added. The mixture was further diluted with EA (400 mL) until two clear layers were obtained. The two layers were separated and the aq. layer was extracted with EA (3×300 mL). The org. layer was washed twice with sat. aq. NaHCO3 (200 mL) and brine (200 mL), dried over MgSO4, filtered and concentrated to dryness. The crude product was triturated with an ether-EA mixture (1-1, 250 mL), washed with ether (2×100 mL), and dried under high vacuum to afford the title aldehyde as a beige solid (23 g, 76% yield).

1. temperatureAfter cooling to −78° C.
2. stirringThe reddish mixture was stirred at −78° C. for 40 min
3. customthe internal temperature below −70° C
4. waitThe reaction proceeded 20 min
5. temperatureOnce the mixture had warmed up to rt
6. customwere obtained
7. customThe two layers were separated
8. extractionthe aq. layer was extracted with EA (3×300 mL)
9. washlayer was washed twice with sat. aq. NaHCO3 (200 mL) and brine (200 mL)
10. dry with materialdried over MgSO4
11. filtrationfiltered
12. concentrationconcentrated to dryness
13. customThe crude product was triturated with an ether-EA mixture (1-1, 250 mL)
14. washwashed with ether (2×100 mL)
15. customdried under high vacuum