反应详情

Cis-4-(4-{4-[(2-Phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-[1,4]diazepane-1-carbonyl)-cyclohexanecarboxylic acid benzyl ester (90 mg) was diluted in 30 mL of methanol and 100 mg of Pd/C (10%) was added. The mixture was placed on a Parr shaker for hydrogenation at 50 psi for 3 hr. The mixture was filtered and the solvent was removed to afford the product 4-(4-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-[1,4]diazepane-1-carbonyl)-cyclohexanecarboxylic acid (30 mg, 40% yield) as a white solid. LCMS for C30H31F3N4O5 calcd. (m/e) 584, observed 585 (M+H).

1. filtrationThe mixture was filtered
2. customthe solvent was removed