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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1509893Generated: October 26, 2026

4-Methoxybenzenesulfonyl chloride → N-[4-Chloro-2-(pyridine-2-carbonyl)-phenyl]-4-methoxy-benzenesulfonamide

https://huagongshe.com/reaction/1509893

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxybenzenesulfonyl chlorideHCID 7401—
Reactant(2-Amino-5-chlorophenyl)(pyridin-2-yl)methanoneHCID 288049—
ProductN-[4-Chloro-2-(pyridine-2-carbonyl)-phenyl]-4-methoxy-benzenesulfonamideHCID 10476253—

Reaction Steps

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 116 mg of (2-Amino-5-chloro-phenyl)-pyridin-2-yl-methanone and 101 mg of 4-methoxy-benzenesulfonyl chloride. 1H-NMR (400 MHz, CDCl3): δ 3.75 (s, 3H), 6.76 (m, 2H, 7.45 (m, 2H), 7.63 (m, 2H), 7.71 (d, 1H, J=8.8 Hz), 7.78 (m, 1H), 7.88 (m, 2H), 8.64 (m, 1H), 10.24 (s, 1H). MS: m/z 403.9 (M++1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08211896B2
Source datasetuspto-grants-2012_07
ORD IDord-0340d62fee164481b85cefc764126f73
Source noteuspto-grants-2012_07