HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Amino-5-chlorophenyl)-pyridin-4-yl methanone → N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-4-(1,1-dimethyl-propyl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Amino-5-chlorophenyl)-pyridin-4-yl methanone | HCID 10214538 | — |
| Reactant | 4-(2-Methylbutan-2-yl)benzene-1-sulfonyl chloride | HCID 22281976 | — |
| Product | N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-4-(1,1-dimethyl-propyl)-benzenesulfonamide | HCID 10026396 | — |
Reaction Steps
The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 116 mg of (2-amino-5-chloro-phenyl)-pyridin-4-yl-methanone and 123 mg of 4-(1,1-dimethyl-propyl)-benzenesulfonylchloride. 1H-NMR (400 MHz, CDCl3): δ 0.59 (t, 3H, J=7.2 Hz), 1.23 (s, 6H), 1.61 (q, 2H, J=7.2 Hz), 7.28 (d, 1H, J=2.8 Hz), 7.36 (m, 2H), 7.53 (m, 3H), 7.67-7.74 (m, 3H), 8.84 (m, 2H), 10.14 (s, 1H). MS: m/z 443.9 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08211896B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-a77c7ca2947745c6a31d46bb65f25024 |
| Source note | uspto-grants-2012_07 |