Hydrochloric Acid → HCID 24856948, compound

Participants

Reaction Steps

HCl in dioxane (3.22 ml, 12.87 mmol) was added to example (6) (0.03 g, 0.051 mmol) followed by a few drops of water. The solution was allowed to stir at RT. After 3 h, the solvents were evaporated, the residue triturated with Et2O and dried under vacuum to afford the title compound (7) (22 mg, 82%). LCMS purity 96%, m/z 527 [M+H]+, 1H NMR (400 MHz, d6-DMSO) δ: 12.6 (1H, s), 9.0 (1H, s), 8.0 (1H, d, J=8.3 Hz), 7.9 (1H, s), 7.5 (3H, m), 7.2 (1H, d, J=8.8 Hz), 6.0 (2H, s), 4.3 (3H, m), 4.2 (2H, d, J=5.4 Hz), 3.7 (6H, s), 2.7 (3H, s), 1.5 (3H, m), 0.8 (6H, m).

Provenance & Evidence