HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Cyanobenzoic acid → 4-(aminomethyl)-N-(2-amino-4-trifluoromethylphenyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Cyanobenzoic acid | HCID 12087 | — |
| Reactant | 4-Trifluoromethyl-1,2-phenylenediamine | HCID 520822 | — |
| Product | 4-(aminomethyl)-N-(2-amino-4-trifluoromethylphenyl)benzamide | HCID 59590543 | 63% |
Reaction Steps
The title compound (195 mg, 63% yield) was prepared as a grey solid from 4-cyano-benzoic acid (294 mg, 2 mmol) and 4-trifluoromethyl-o-phenylenediamine (422 mg, 2.4 mmol) by an analogous procedure to that described in example 8. LC-MS (m/z) 310 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08211901B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-7b5f520783d740e9a619d2f5b7a53337 |
| Source note | uspto-grants-2012_07 |