HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
6-(6,7-Dimethoxyquinazolin-4-yloxy)-1-naphthoic acid → N-(4-((2-aminophenyl)carbamoyl)benzyl)-6-(6,7-dimethoxyquinazolin-4-yloxy)-1-naphthamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 6-(6,7-Dimethoxyquinazolin-4-yloxy)-1-naphthoic acid | HCID 24823734 | — |
| Edukt | 4-(Aminomethyl)-N-(2-aminophenyl)benzamide | HCID 58817250 | — |
| Produkt | N-(4-((2-aminophenyl)carbamoyl)benzyl)-6-(6,7-dimethoxyquinazolin-4-yloxy)-1-naphthamide | HCID 49805262 | 72% |
Reaktionsschritte
The title compound (43.1 mg, 72% yield) was prepared as a brown solid from 6-(6,7-dimethoxyquinazolin-4-yloxy)-1-naphthoic acid (37.6 mg, 0.1 mmol) and 4-(aminomethyl)-N-(2-aminophenyl)benzamide (28.9 mg, 0.12 mmol) by an analogous procedure to that described in example 16. LC-MS (m/z) 600 (M+1).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08211901B2 |
| Quelldatensatz | uspto-grants-2012_07 |
| ORD ID | ord-5cd9c8d0e9d3471896b8bc584380d2d6 |
| Quellennotiz | uspto-grants-2012_07 |