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HRID 1510008作成日：2026年10月26日

6-(6,7-Dimethoxyquinazolin-4-yloxy)-1-naphthoic acid → N-(3-((2-aminophenyl)carbamoyl)benzyl)-6-(6,7-dimethoxyquinazolin-4-yloxy)-1-naphthamide

https://huagongshe.com/reaction/1510008

反応式

関与物質

役割名称HCID仕込み量
反応物6-(6,7-Dimethoxyquinazolin-4-yloxy)-1-naphthoic acidHCID 24823734—
反応物3-(aminomethyl)-N-(2-aminophenyl)benzamideHCID 59590553—
生成物N-(3-((2-aminophenyl)carbamoyl)benzyl)-6-(6,7-dimethoxyquinazolin-4-yloxy)-1-naphthamideHCID 4982184681%

反応手順

The title compound (48.5 mg, 81% yield) was prepared as a brown solid from 6-(6,7-dimethoxyquinazolin-4-yloxy)-1-naphthoic acid (37.6 mg, 0.1 mmol) and 3-(aminomethyl)-N-(2-aminophenyl)benzamide (28.9 mg, 0.12 mmol) by an analogous procedure to that described in example 16. LC-MS (m/z) 600 (M+1).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08211901B2
出典データセットuspto-grants-2012_07
ORD IDord-ad76498a26ba4bcca46869f35316ffaf
出典メモuspto-grants-2012_07