4-[5-(4-(benzyloxycarbonyl)piperazin-1-yl)pyridin-2-yl]-3,4-dihydro-2H-quinoxaline-1-carboxylic acid tert-butyl ester → 4-(5-(piperazin-1-yl)pyridin-2-yl)-3,4-dihydro-2H-quinoxaline-1-carboxylic acid tert-butyl ester

Participants

Reaction Steps

5.08 g of 4-[5-(4-(benzyloxycarbonyl)piperazin-1-yl)pyridin-2-yl]-3,4-dihydro-2H-quinoxaline-1-carboxylic acid tert-butyl ester are placed in 240 ml of ethanol in a Parr bottle. 2 g of 10% Pd/C (50% in water) are added. The reaction medium is stirred at 35° C. under 45 psi hydrogen for 3.5 h. It is filtered on a Whatman filter under an inert atmosphere and then the filter residue is washed many times with methanol. The methanol is evaporated under reduced pressure. 3.57 g of 4-(5-(piperazin-1-yl)pyridin-2-yl)-3,4-dihydro-2H-quinoxaline-1-carboxylic acid tert-butyl ester are obtained.

Provenance & Evidence