HRID1510070

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID302628

3-Fluoro-2-methylphenol

C7H7FO

结构：CC(C)(C)OC(=O)N1CCN(C(=O)c2c(Cl)n(-c3ccsc3)c3ccccc23)CC1

HCID66920293

未命名化合物

PRODUCTS

生成物

结构：Cc1c(F)cccc1Oc1c(C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)c2ccccc2n1-c1ccsc1

HCID66920279

未命名化合物

PROCEDURE

实验过程

From the compound of step 3 (50 mg, 112 μmol), the title compound was prepared analogously as described in example 1, step 2, using 3-fluoro-2-methylphenol. Yield: 11 mg.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-22ec4c90520746b7a131ae4698b65f70
来源数据集: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08211885B2
来源说明: uspto-grants-2012_07

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]([C:25]3[CH:29]=[CH:28][S:27][CH:26]=3)[C:17]=2Cl)=[O:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:31][C:32]1[C:33]([CH3:39])=[C:34]([OH:38])[CH:35]=[CH:36][CH:37]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]([C:25]3[CH:29]=[CH:28][S:27][CH:26]=3)[C:17]=2[O:38][C:34]2[CH:35]=[CH:36][CH:37]=[C:32]([F:31])[C:33]=2[CH3:39])=[O:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]