2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl → HCID 66920433, compound

Participants

Reaction Steps

A solution of 2-methylbenzylzinc chloride (1.95 ml, 973 μmol, 0.5 M in THF) was added dropwise at −78° C. to a solution of B-OM-9-BBN (0.97 ml, 973 μmol, 1 M in hexane). The cooling bath was removed and the mixture was stirred at room temperature for 30 min. DMF (2 ml) was added, followed by the compound of step 5 (50 mg, 97.3 μmol), palladium(II) acetate (2.18 mg, 9.73 μmol) and S-PHOS (7.99 mg, 19.5 μmol). The reaction mixture was heated to 100° C. and stirred for 4 h. The mixture was diluted with water and extracted with EA. The organic layer was separated, dried over sodium sulfate, filtered and evaporated under reduced pressure. The residue was purified by preparative HPLC. The eluate was lyophilized overnight to give 14 mg of the title compound.

Provenance & Evidence