5-Fluoro-2-methylbenzyl bromide → HCID 66920481, compound

HRID 1510090Notes

Reaction equation

HRID 1510090 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:17]=2Cl)=[O:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:32][C:33]1[CH:34]=[CH:35][C:36]([CH3:41])=[C:37]([CH:40]=1)[CH2:38]Br>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:17]=2[CH2:38][C:37]2[CH:40]=[C:33]([F:32])[CH:34]=[CH:35][C:36]=2[CH3:41])=[O:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27746055-Fluoro-2-methylbenzyl bromideHCID 45257316HCID 45257316, compound

Product 1

HCID 66920481HCID 66920481, compound

Procedure

From the compound of example 16, step 1, (150 mg, 341 μmol) the title compound was prepared analogously as described in example 17, step 1, using 5-fluoro-2-methylbenzyl bromide. Yield: 9 mg.

Sources & evidence

ORD record
ord-052ee6c795bf45a9be053e981f9fa392
Source dataset
uspto-grants-2012_07
Patent number
US08211885B2

Reaction notes

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