HCID 66920449, compound → HCID 52949001, compound

Participants

Reaction Steps

The compound of step 1 (20 mg, 30 μmol) was dissolved in ethanol (5 ml), palladium on carbon (4 mg) was added, and the mixture was stirred under an atmosphere of hydrogen at a pressure of 1.5 bar at room temperature for 3 h. The mixture was filtered over a pad of celite and evaporated under reduced pressure. The residue was dissolved in DCM (20 ml), TFA (5 ml) was added, and the mixture was stirred at room temperature for 1 h. The solvents were evaporated and the obtained solid was purified by preparative HPLC. The eluate was lyophilized overnight, the residue dissolved in a small quantity of MOH, mixed with hydrochloric acid (0.1 M) and lyophilized overnight. 4 mg of the title compound were obtained in the form of the [2-(3-fluoro-2-methyl-benzyl)-6-(2-hydroxy-ethoxy)-1-phenyl-1H-indol-3-yl]-piperazin-1-yl-methanone hydrochloride.

Provenance & Evidence