Dimethylformamide → HCID 66920266, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of the compound of step 2 (350 mg, 0.58 mmol), zinc cyanide (135 mg, 1.15 mmol) and tetrakis(triphenylphosphin)palladium(0) (133 mg, 0.12 mmol) in DMF (8 ml) was heated to 80° C. for 1 h. After cooling to room temperature, the mixture was partitioned between water and EA and the aqueous phase extracted with EA. The combined organic layers were dried over sodium sulfate, filtered and concentrated. The residue was purified by preparative HPLC and lyophilized overnight. 151 mg of the title compound were obtained.

Provenance & Evidence