Trifluoroacetic acid → HCID 52944034, compound

Participants

Reaction Steps

The compound of step 1 (88 mg, 133 μmol) was dissolved in DCM (20 ml), TFA (5 ml) was added, and the mixture was stirred at room temperature for 1 h. The solvents were evaporated and the obtained solid was purified by preparative HPLC. The eluate was lyophilized overnight. The residue was dissolved in a small quantity of MOH, mixed with hydrochloric acid (0.1 M) and lyophilized overnight. 45 mg of the title compound were obtained in the form of the [2-(5-fluoro-2-methyl-phenoxy)-1-phenyl-3-(piperazine-1-carbonyl)-1H-indol-6-yloxy]-acetic acid hydrochloride.

Provenance & Evidence