HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → Veonetinib
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 5-(2-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)ethyl)-5-azaspiro[2.4]-heptan-7-one | HCID 46176481 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Veonetinib | HCID 46176482 | 79.7% |
Reaction Steps
The above product from Example 2 (75 mg) was dissolved into MeOH (8 ml) and stirred at RT. NaBH4 (75 mg) was added to the reaction and stirred at RT for 30 min. The reaction was evaporated and purified by column chromatography to give title compound (60 mg). Mass: (M+1), 478
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08211911B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-b7948eb6f2c34b8abef886925e5ac23b |
| Source note | uspto-grants-2012_07 |