反应详情

温度

60 °C

To a solution of (1-isopropyl-1H-indol-6-yl)methanol (0.18 g, 0.97 mmol) in CCl4(5 mL) was added manganese dioxide (0.13 g, 1.45 mmol). After stirring at 60° C. for 1 h, then 77° C. for 2 h, filtered reaction mixture through celite and concentrated. Partitioned crude compound between saturated sodium bicarbonate and EtOAc, washed with H2O and brine, dried with Na2SO4, and concentrated. The crude compound was chromatographed to give the desired product.

1. wait77° C. for 2 h
2. filtrationfiltered
3. customreaction mixture through celite and
4. concentrationconcentrated
5. customPartitioned crude compound between saturated sodium bicarbonate and EtOAc
6. washwashed with H2O and brine
7. dry with materialdried with Na2SO4
8. concentrationconcentrated
9. customThe crude compound was chromatographed