Triphenylphosphine → HCID 66789913, compound

Participants

Reaction Steps

Methyl 3-hydroxybenzoate (10.0 g, 65.7 mmol) in toluene (65.7 ml) was cooled to 0° C. and added 1-cyclopropylethanol (6.43 ml, 65.7 mmol), triphenylphosphine (18.9 g, 72.3 mmol), and DIAD (14.1 ml, 72.3 mmol). The reaction warmed to rt for sixteen hours. The reaction mixture was filtered through a fritted funnel to remove precipitated triphenylphosphine oxide and washed with toluene. The filtrate was concentrated. The residue was purified by column chromatography on silica gel Biotage 65i, eluting with 10% ethyl acetate/hexanes to give a colorless oil.

Provenance & Evidence