反应详情

To a 0° C. solution of methyl 3-(2-chloroethoxy)benzoate (5.61 g, 26.1 mmol) in THF (50 mL) was added potassium tert-butoxide (3.67 g, 32.7 mmol). When the addition was complete the reaction was allowed to warm to rt. After stirring at rt overnight the reaction was quenched with water. The solution was extracted with diethyl ether (three times), dried over MgSO4, and concentrated under vacuum. Purification by silica gel chromatography afforded the desired product.

1. additionWhen the addition
2. customwas quenched with water
3. extractionThe solution was extracted with diethyl ether (three times)
4. dry with materialdried over MgSO4
5. concentrationconcentrated under vacuum
6. customPurification by silica gel chromatography