Potassium tert-butoxide → Methyl 3-(ethenyloxy)benzoate

HRID 1510136Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1510136
Cl[CH2:2][CH2:3][O:4][C:5]1[CH:6]=[C:7]([CH:12]=[CH:13][CH:14]=1)[C:8]([O:10][CH3:11])=[O:9].CC(C)([O-])C.[K+]>C1COCC1>[CH:3]([O:4][C:5]1[CH:6]=[C:7]([CH:12]=[CH:13][CH:14]=1)[C:8]([O:10][CH3:11])=[O:9])=[CH2:2]

Komponenten

4

Edukt 2

HCID 23665647Potassium tert-butoxideHCID 43532224Methyl 3-(2-chloroethoxy)benzoate

Produkt 1

HCID 57336627Methyl 3-(ethenyloxy)benzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a 0° C. solution of methyl 3-(2-chloroethoxy)benzoate (5.61 g, 26.1 mmol) in THF (50 mL) was added potassium tert-butoxide (3.67 g, 32.7 mmol). When the addition was complete the reaction was allowed to warm to rt. After stirring at rt overnight the reaction was quenched with water. The solution was extracted with diethyl ether (three times), dried over MgSO4, and concentrated under vacuum. Purification by silica gel chromatography afforded the desired product.

Aufarbeitung

  1. additionWhen the addition
  2. customwas quenched with water
  3. extractionThe solution was extracted with diethyl ether (three times)
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated under vacuum
  6. customPurification by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-15085b458052449c888e40ed50272290
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08211904B2

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