HCID 66790218, compound → HCID 66790967, compound

Participants

Reaction Steps

A solution of methyl 2,2-dimethyl-1,2-dihydroquinoline-8-carboxylate (Example 47, step 3) (1.00 g, 4.63 mmol) in methanol (20 mL) containing a catalytic amount of 10% palladium on carbon was placed under an atmosphere of hydrogen at ambient pressure and temperature. After stirring at room temperature for 2 h the reaction mixture was filtered through a pad of celite and concentrated under vacuum. Purification by silica gel chromatography (2.5% EtOAc/hexanes) afforded the desired compound.

Provenance & Evidence