HCID 12030321, compound → HCID 66790620, compound

Participants

Reaction Steps

To a 0° C. solution of 3,3-dimethyl-6-[(4-methylphenyl)sulfonyl]-6-aza-3-silabicyclo[3.1.0]hexane (0.5 g, 1.8 mmol) in THF (10 ml) was added lithium aluminum hydride (11.0M THF, 5.33 mL, 5.33 mol). After stirring at rt overnight, the reaction was quenched by the sequential addition of H2O (0.2 mL), 1N NaOH (0.2 mL), and H2O (0.6 mL). The mixture was filtered through a pad of celite and concentrated under vacuum. Purification by silica gel chromatography (20% EtOAc/hexanes) afforded the desired product.

Provenance & Evidence