HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl 2-methyl-4-oxopiperidine-1-carboxylate → Benzyl (2S)-2-methyl-4-oxopiperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl 2-methyl-4-oxopiperidine-1-carboxylate | HCID 46941997 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Benzyl (2S)-2-methyl-4-oxopiperidine-1-carboxylate | HCID 57475593 | — |
Reaction Steps
The crude Racemic benzyl 2-methyl-4-oxopiperidine-1-carboxylate was dissolved in MeOH and chromatographed on a 10 cm Chiralpak AD column eluting with 100% MeOH in 2.5 g injections to give the two separated enantiomers. The desired enantiomer eluted first, 95% ee.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08211904B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-b930b4c6992d4d1d90b8a4e5ea707c32 |
| Source note | uspto-grants-2012_07 |