Cyclohexylamine → HCID 178461164, compound

Participants

Reaction Conditions

Reaction Steps

Benzyl (5R,7S)-1-(3-fluorophenyl)-4-imino-7-methyl-2-oxo-1,3,8-triazaspiro[4.5]decane-8-carboxylate (27.2 g, 0.066 moles) was dissolved in 100 mL toluene, cyclohexylamine (60 mL, 0.523 moles) was added and the mixture was heated to 110° C. over the weekend in a 1 L roundbottom flask fitted with a condenser. The reaction was diluted with CHCl3 and MeOH until soluble and washed with 1 Normal HCl three times to remove excess cyclohexylamine. The organic was dried with MgSO4, filtered and concentrated to give the product which was used in the next step without further purification.

Provenance & Evidence