Diisopropylethylamine → HCID 178461163, compound

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate	HCID 151348	—
Reactant	HCID 66790968	HCID 66790968	—
Reactant	HCID 178461160	HCID 178461160	—
Solvent	Water	HCID 962	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 178461163	HCID 178461163	—

Reaction Conditions

Temperature	50 °C

Reaction Steps

To a solution of 11-9 (0.309 g, 0.861 mmol) in DMF (10 mL) was added: 2,2-dimethyl-1,2-dihydroquinoline-8-carboxylic acid (0.175 g, 0.861 mmol), diisopropyethylamine (0.334 g, 2.58 mmol) and BOP reagent (0.381 g, 0.861 mmol). After stirring at 50° C. overnight the reaction mixture was diluted with water and extracted using chloroform (three times). The combined organic layer were dried over MgSO4 and concentrated under vacuum. Purification by silica gel chromatography (4% methanol/chloroform/1% triethylamine) afforded the desired product.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08211904B2
Source dataset	uspto-grants-2012_07
ORD ID	ord-c29ace8fd7bf4b879683dc88b792f8ed
Source note	uspto-grants-2012_07