反应详情

2-(trimethylsilyl)ethyl 4-oxo-2-vinyl-3,4-dihydropyridine-1(2H)-carboxylate (29.1 g, 109 mmol) in acetic acid (500 ml) was added zinc dust (42.7 g, 652 mmol). The solution stirred at room temperature for 2 hrs and was filtered through a pad of celite. The solvent was evaporated under reduced pressure and the product was purified by column chromatography on silica gel Biotage 65i, eluting with 20% ethyl acetate/hexanes.

1. filtrationwas filtered through a pad of celite
2. customThe solvent was evaporated under reduced pressure
3. customthe product was purified by column chromatography on silica gel Biotage 65i
4. washeluting with 20% ethyl acetate/hexanes