反应详情

To 8 (31.7 g, 72.07 mmol, 1 eq) dissolved in dry MeOH (800 mL) under argon was added sodium methanolate (17.3 g, 302.7 mmol, 4.2 eq). After being stirred for 1 h, Amberlite IR 120 (300 g) was added and the mixture was stirred for 15 min up to pH=7. The solution was filtered through alumina. The cake was washed with MeOH (150 mL) and the organic layer was concentrated. The crude was engaged in the next step.

1. stirringthe mixture was stirred for 15 min up to pH=7
2. filtrationThe solution was filtered through alumina
3. washThe cake was washed with MeOH (150 mL)
4. concentrationthe organic layer was concentrated