Toluene → 4-Methoxy-4'-methylbiphenyl

Participants

Reaction Steps

Using a THF solution of p-tolylmagnesium bromide (1.18 mL, 1.02 M, 1.2 mmol) and 1-methoxy-4-chlorobenzene (142.6 mg, 1.0 mmol) as starting materials, the reaction was performed at a scale of 1.0 mmol at 60° C. for 24 hours in the same manner as in Example 2. After performing silica gel column chromatography (toluene=15, 30 and 50% in hexane), the above compound was obtained as a white solid (0.182 g, yield=92%, purity=>99% (GC analysis)).

Provenance & Evidence