Toluene → 4-Fluoro-4'-methoxybiphenyl

HRID 1510180Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1510180
C1COCC1.[CH3:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([Mg]Br)=[CH:10][CH:9]=1.Cl[C:17]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=1.C1(C)C=CC=CC=1>CCCCCC>[F:23][C:20]1[CH:21]=[CH:22][C:17]([C:11]2[CH:12]=[CH:13][C:8]([O:7][CH3:6])=[CH:9][CH:10]=2)=[CH:18][CH:19]=1

Komponenten

6

Edukt 4

HCID 1140TolueneHCID 8028TetrahydrofuranHCID 9604Benzene, 1-chloro-4-fluoro-HCID 178491912HCID 178491912, Verbindung

Produkt 1

HCID 27589974-Fluoro-4'-methoxybiphenylAusbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8058HexaneLösungsmittel

Versuchsvorschrift

Using a THF solution of p-methoxyphenylmagnesium bromide (1.88 mL, 0.64 M, 1.2 mmol) and 1-chloro-4-fluorobenzene (130.6 mg, 1.0 mmol) as starting materials, the reaction was performed at a scale of 1.0 mmol at 60° C. for 24 hours in the same manner as in Example 2. After performing silica gel column chromatography (toluene=15, 30 and 50% in hexane), the above compound (0.184 g, yield=91%, purity=>99% (GC analysis)) was obtained as a white solid.

Aufarbeitung

  1. customthe above compound (0.184 g, yield=91%, purity=>99% (GC analysis)) was obtained as a white solid

Quellen und Nachweise

ORD-Eintrag
ord-f5a65f47eeb4427aa87ee1b16a6a6723
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08211820B2

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