Tetrahydrofuran → 3,4-Difluoro-4'-methoxy-1,1'-biphenyl

Participants

Reaction Steps

Using a THF solution of p-methoxyphenylmagnesium bromide (2.34 mL, 0.64 M, 1.5 mmol), 4-chloro-1,2-difluorobenzene (148.6 mg, 1.0 mmol), FeF3.3H2O (8.34 mg, 0.05 mmol) and 1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride (64.1 mg, 0.15 mmol) as starting materials, the reaction was performed at a scale of 1.0 mmol at 60° C. for 24 hours, and then at 80° C. for 12 hours, in the same manner as in Example 2. After performing silica gel column chromatography (toluene=15, 30 and 50% in hexane), the above compound was obtained as a white solid (0.215 g, yield=92%, purity=>99% (GC analysis)).

Provenance & Evidence