Toluene → HCID 15856747, compound

Participants

Reaction Steps

Using a THF solution of p-methoxyphenylmagnesium bromide (2.34 mL, 0.64 M, 1.5 mmol) and 1-chloro-2-fluorobenzene (130.6 mg, 1.0 mmol) as starting materials, the reaction was performed at a scale of 1.0 mmol at 60° C. for 24 hours, then at 80° C. for 12 hours in the same manner as in Example 15. After performing silica gel column chromatography (toluene=15, 30 and 50% in hexane), the above compound (0.135 g, yield=68%, purity=>97% (GC analysis)) was obtained as a white solid.

Provenance & Evidence