HCID 69230961, compound → HCID 69236551, compound

Participants

Reaction Steps

(S)-2-((3S,4S)-4-(2-(benzhydryloxy)ethyl)-3-hydroxypiperidin-1-yl)-1-(4-fluorophen-yl)ethyl acetate (8d′). 1H-NMR (CDCl3; 400 MHz): 1.28-1.38 (m, 2H, H-4, H-5ax), 1.54-1.65 (2H, m, H-5eq, CH2CH2O), 1.83-1.92 (m, 1H, H-6ax), 1.97-1.99 (t, 1H, J=13.2 Hz, H-2ax), 2.07 (s, 3H, OCOCH3), 2.11-2.14 (t, 1H, J=8.8 Hz, CHHCH2O), 2.54-2.58 (dd, J=13.6, 4.8 Hz, 1H, NCHHCHAr), 2.70-2.73 (brd, 1H, J=11.2 Hz, H-6eq), 2.79-2.85 (m, 1H, NCHHCHAr), 3.01-3.05 (dd, 1H, J=10.4, 2.8 Hz, H-2eq), 3.31-3.36 (m, 1H, H-3ax), 3.48-3.53 (m, 1H, CH2CHHO), 3.55-3.60 (m, 1H, CH2CHHO), 5.36 (s, 1H, PhCH(O)Ph), 5.87-5.90 (dd, 1H, J=8.4, 4.8 Hz, CHOCOCH3), 6.99-7.04 (t, 2H, ArH), 7.22-7.33 (m, 12H, ArH). [a]25D=+13.30° (c=1.0, CHCl3).

Provenance & Evidence