Hydrogen chloride-ethyl acetate → HCID 57663909, compound

Participants

Reaction Steps

To a suspension of N-[4-(4-pyridinyl)phenyl]-1-tert-butoxycarbonylindoline-2-carboxamide (100 mg) in ethyl acetate (0.60 mL) was added 4N hydrogen chloride-ethyl acetate (2.41 mL) and the mixture was stirred at ambient temperature for 1.5 hours. The resulting mixture was diluted with n-hexane (6.0 mL) and the solid was collected by filtration, and then washed with ethyl acetate/n-hexane (1:2, 1.0 mL) to give N-[4-(4-pyridinyl)phenyl]indoline-2-carboxamide (80 mg) as off-white crystals.

Provenance & Evidence