5'-nitro-4-(3-triflouromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl → 4-(3-trifluoromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-ylamine

Participants

Reaction Steps

To a solution of 5′-nitro-4-(3-trifluoromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl (500 mg, 1.42 mmol) from above in ethanol (15 mL) was added 10% palladium on carbon (100 mg). The mixture was hydrogenated at 50 psi for 2 hr. The mixture was filtered over celite and the solvents were evaporated to give 4-(3-trifluoromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-5′-ylamine that was used in the next step with further purification. LCMS calcd for C17H18F3N3 (m/e) 321, obsd 322 (M+H).

Provenance & Evidence