HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-5-nitropyridine → 6-[4-(2-Trifluoromethyl-phenyl)-piperazin-1-yl]-pyridin-3-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-5-nitropyridine | HCID 78308 | — |
| Reactant | 1-[2-(Trifluoromethyl)phenyl]piperazine | HCID 2777670 | — |
| Reactant | 4-(3-trifluoromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-ylamine | HCID 59371245 | — |
| Reactant | 6-[4-(2-Trifluoroethyl-phenyl)-piperazin-1-yl]-pyridin-3-ylamine | HCID 68637339 | — |
| Product | 6-[4-(2-Trifluoromethyl-phenyl)-piperazin-1-yl]-pyridin-3-ylamine | HCID 59371237 | — |
Reaction Steps
With a method similar to that used for the preparation of 4-(3-trifluoromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-5′-ylamine above, 6-[4-(2-trifluoroethyl-phenyl)-piperazin-1-yl]-pyridin-3-ylamine was prepared from 2-chloro-5-nitropyridine and 1-(2-trifluoromethyl-phenyl)-piperazine followed by hydrogenation. LCMS calcd for C16H17F3N4 (m/e) 322, obsd 323 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08211914B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-f52914a191b94b6b9c3d0bbce0b8e136 |
| Source note | uspto-grants-2012_07 |