Lithium Hydroxide → HCID 46833516, compound

Participants

Reaction Steps

To 4-(4-{5-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-pyridin-2-yl}-piperazin-1-yl)-benzoic acid ethyl ester (130 mg, 0.23 mmol) dissolved in a 1:1 mixture of THF/methanol (2 mL) was added 1N LiOH (2.60 mL, 2.60 mmol). The mixture was stirred at rt overnight. The crude mixture was acidified to pH=1 and purified by HPLC to give 4-(4-{5-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-pyridin-2-yl}-piperazin-1-yl)-benzoic acid. The NMR spectrum obtained on the sample is compatible with its structure. LCMS calcd for C27H22F3N5O4 (m/e) 537, obsd 538 (M+H).

Provenance & Evidence