4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 17751106, compound

HRID 1510300Notes

Reaction equation

HRID 1510300 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:10]=[C:11]([O:13][CH2:14][CH3:15])[CH:12]=1)[C:7]([OH:9])=O)[CH3:2].[NH2:16][C:17]1[S:18][CH:19]=[C:20]([CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])[N:21]=1>>[CH2:26]([O:25][C:23](=[O:24])[CH2:22][C:20]1[N:21]=[C:17]([NH:16][C:7](=[O:9])[C:6]2[CH:10]=[C:11]([O:13][CH2:14][CH3:15])[CH:12]=[C:4]([O:3][CH2:1][CH3:2])[CH:5]=2)[S:18][CH:19]=1)[CH3:27]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 7211363,5-diethoxybenzoic acid

Product 1

HCID 17751106HCID 17751106, compoundYield 86%

Procedure

[2-(3,5-Diethoxy-benzoylamino)-thiazol-4-yl]-acetic acid ethyl ester (80 mg, 86%) was prepared from 3,5-diethoxybenzoic acid (52 mg, 0.25 mmol) and ethyl 2-aminothiazol-4-ylacetate (93 mg) following synthetic description A.

Sources & evidence

ORD record
ord-073eb8b4cf84485bb94531b91badf546
Source dataset
uspto-grants-2012_07
Patent number
US08211925B2

Reaction notes

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