2-Amino-1,3-thiazole-5-carbaldehyde → N-(5-Formylthiazol-2-yl)-3-isopropoxy-5-phenoxybenzamide

HRID 1510309Notes

Reaction equation

HRID 1510309 reaction equation
[CH:1]([C:3]1[S:7][C:6]([NH2:8])=[N:5][CH:4]=1)=[O:2].[CH:9]([O:12][C:13]1[CH:14]=[C:15]([CH:19]=[C:20]([O:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:21]=1)[C:16](O)=[O:17])([CH3:11])[CH3:10]>>[CH:1]([C:3]1[S:7][C:6]([NH:8][C:16](=[O:17])[C:15]2[CH:19]=[C:20]([O:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:21]=[C:13]([O:12][CH:9]([CH3:10])[CH3:11])[CH:14]=2)=[N:5][CH:4]=1)=[O:2]

Participants

3

Reactant 2

HCID 27377982-Amino-1,3-thiazole-5-carbaldehydeHCID 669698623-Isopropyloxy-5-phenoxybenzoic acid

Product 1

HCID 86649453N-(5-Formylthiazol-2-yl)-3-isopropoxy-5-phenoxybenzamideYield 41%

Procedure

N-(5-Formylthiazol-2-yl)-3-isopropoxy-5-phenoxybenzamide (460 mg) was prepared in 41% yield from 5-formyl-2-aminothiazole (600 mg, 4.7 mmol) and 3-isopropyloxy-5-phenoxybenzoic acid (800 mg, 2.95 mmol) following general synthetic description A.

Sources & evidence

ORD record
ord-e3f8a60c79b04077865c1f82c8c6bda0
Source dataset
uspto-grants-2012_07
Patent number
US08211925B2

Reaction notes

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