Pyrrolidine → HCID 59334985, compound

Participants

Reaction Steps

400 mg of 1-methyl-6-nitro-1H-indole-3-carboxylic acid are dissolved in 4 ml dimethylformamide, combined with 774 μl N,N-diisopropyl-N-ethyl-amine as well as 583 mg O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium-tetrafluoroborate (TBTU) and stirred for 45 minutes at ambient temperature. 225 μl of pyrrolidine are added and the mixture is stirred for 5 hours at ambient temperature. Then it is divided between water and ethyl acetate, the organic phase is washed with saturated sodium chloride solution and dried on magnesium sulphate. The solvents are eliminated in vacuo.

Provenance & Evidence