HCID 68861173, compound → HCID 57758710, compound

HRID 1510369Notes

Reaction equation

HRID 1510369 reaction equation
C(OC([N:11]1[CH2:15][CH:14]([O:16][CH3:17])[C:13]([NH:19][C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])([CH3:18])[CH2:12]1)=O)C1C=CC=CC=1>CO.[C].[Pd].[H][H]>[C:23]([O:22][C:20]([NH:19][C:13]1([CH3:18])[CH:14]([O:16][CH3:17])[CH2:15][NH:11][CH2:12]1)=[O:21])([CH3:26])([CH3:25])[CH3:24]

Participants

5

Reactant 1

HCID 68861173HCID 68861173, compound

Product 1

HCID 57758710HCID 57758710, compound

Reagents, catalysts & solvents 3

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolventHCID 178418361HCID 178418361, compoundSolvent

Procedure

To a solution of 1-benzyloxycarbonyl-3-(tert-butoxycarbonylamino)-4-methoxy-3-methylpyrrolidine (fraction α) (0.29 g, 0.8 mmol) in methanol (10 mL), 5% palladium-carbon catalyst (water content, 50%; 0.15 g) was added, and the suspension was stirred at room temperature for 16.5 hours in hydrogen atmosphere. The reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure to obtain the title compound as a colorless oily product. This product was used in the subsequent reaction with no further purification.

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-7613647c018c4dce846bb74991c27eb5
Source dataset
uspto-grants-2012_07
Patent number
US08211910B2

Reaction notes

Loading…