HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 178432942, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-(3-Phenyl-1,2-oxazol-5-yl)methanamine | HCID 2764165 | — |
| Reactant | 2-chloro-N-(3-cyclopropyl-1H-pyrazol-5-yl)-6-methylpyrimidin-4-amine | HCID 59819615 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | HCID 178432942 | HCID 178432942 | 58% |
Reaction Conditions
| Temperature | 160 °C |
|---|
Reaction Steps
A mixture of 2-chloro-6-methylpyrimidin-4-yl-(5-cyclopropyl-1H-pyrazol-3-yl)-amine (1.9 g, 7.6 mmol), 3-phenylisoxazol-5-ylmethylamine (1.7 g, 9.9 mmol) and diisopropylethylamine (1.8 mL, 11 mmol) in 1-butanol (30 mL) was heated to 160° C. in a 50 mL sealed tube for 8 h. The hot mixture was filtered to give the desired product (1.7 g, 58%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08211929B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-0ec21bca8b814c13b8756d3900e311a8 |
| Source note | uspto-grants-2012_07 |