反应详情

A mixture of ethyl 4-bromo-5-(4-chlorophenyl)isoxazole-3-carboxylate (213 mg, 0.70 mmol) and cyclopentylamine (0.70 mL, 7.0 mmol) in absolute ethanol (8 mL) was heated to reflux overnight. The volatiles were removed in vacuo and the compound was purified by silica gel chromatography eluting with 2% methanol with dichloromethane to afford the title compound: (0.21 g, 0.57 mmol). MS (ESI) m/z (M+H+): 370.9/368.8.

1. temperaturewas heated
2. temperatureto reflux overnight
3. customThe volatiles were removed in vacuo
4. customthe compound was purified by silica gel chromatography
5. washeluting with 2% methanol with dichloromethane