Potassium Carbonate → 4-Chloro-5-(4-(trifluoromethyl)phenyl)-N-(3-hydroxyphenyl)isoxazole-3-carboxamide

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-chloro-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carbonyl chloride (15 mg, 0.05 mmol), 3-aminophenol (12.7 mg, 0.10 mmol) and potassium carbonate (7 mg, 0.05 mmol) in dichloromethane (8 mL) was heated to 45° C. overnight. The volatiles were removed in vacuo and the compound was purified by silica gel chromatography eluting with 3% methanol in dichloromethane to afford the title compound: (7.7 mg, 0.02 mmol). MS (ESI) m/z (M+H+): 383.1.

Provenance & Evidence