HCID 67121204, compound → HCID 25182301, compound

Participants

Reaction Steps

To a stirred solution of N-cyclopentyl-5-(4-(trifluoromethyl)phenyl)-4-vinylisoxazole-3-carboxamide (70 mg, 0.2 mmol) in ethanol (2 mL), palladium on carbon (5%) (5 mg) was added and the reaction mixture was then placed under a hydrogen atmosphere (balloon) for 2 hours. After this time the crude mixture was filtered through celite and concentrated in vacuo. Purification by silica gel chromatography eluting with heptane increasing to heptane to 15% ethylacetate in heptane afforded the title compound (36 mg, 0.1 mmol).

Provenance & Evidence