HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
O-(2-(Vinyloxy)ethyl)hydroxylamine → 2-(4-Bromo-2-fluorophenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (2-hydroxyethoxy)-amide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | O-(2-(Vinyloxy)ethyl)hydroxylamine | HCID 21867017 | — |
| Edukt | 2-(4-Bromo-2-fluorophenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid | HCID 57636936 | — |
| Edukt | 2-(4-Bromo-2-fluorophenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (2-vinyloxyethoxy)-amide | HCID 86672323 | — |
| Produkt | 2-(4-Bromo-2-fluorophenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (2-hydroxyethoxy)-amide | HCID 11234968 | 60% |
Reaktionsschritte
Preparation of 2-(4-bromo-2-fluorophenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (2-vinyloxyethoxy)-amide: 2-(4-Bromo-2-fluorophenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (0.020 g, 0.059 mmol) was coupled as described previously in Example 154 using O-(2-vinyloxy-ethyl)-hydroxylamine to yield 0.015 g (60%) pure desired product as a yellow solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08211920B2 |
| Quelldatensatz | uspto-grants-2012_07 |
| ORD ID | ord-2e249bf7a87545a88530f0c518a8b07e |
| Quellennotiz | uspto-grants-2012_07 |