Sodium Hydroxide → HCID 61834499, compound

HRID 15107Notes

Reaction equation

HRID 15107 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([NH:16]C(=O)C)[CH:5]=[CH:6][C:7]=1[C:8]([N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)=[O:9].[OH-].[Na+]>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[C:8]([N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)=[O:9])[NH2:16]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 68637681N-[3-methyl-4-(morpholin-4-yl-carbonyl)-phenyl]-acetamide

Product 1

HCID 61834499HCID 61834499, compound

Conditions

Temperature
65 °C

Procedure

700.0 mg (2.67 mmol) N-[3-methyl-4-(morpholin-4-yl-carbonyl)-phenyl]-acetamide are combined with 7 ml 4-molar sodium hydroxide solution and stirred overnight at 65° C. The reaction mixture is poured onto ice water and extracted with ethyl acetate. The organic phase is dried over magnesium sulphate and evaporated down i. vac.

Workup

  1. additionThe reaction mixture is poured onto ice water
  2. extractionextracted with ethyl acetate
  3. dry with materialThe organic phase is dried over magnesium sulphate
  4. customevaporated down i

Sources & evidence

ORD record
ord-0aa6374f81f648318495f33d600113bb
Source dataset
uspto-grants-2010_06
Patent number
US07732466B2

Reaction notes

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