Hydrogen chloride-ethyl acetate → HCID 68931821, compound

Participants

Reaction Steps

To a solution of 53 mg of 1-(2-(4-((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)-2-methylpiperidin-1-yl)ethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one in 1 mL of ethyl acetate, 0.23 mL of a 4.0 mol/L hydrogen chloride/ethyl acetate solution was added at room temperature, and after stirring, the solid was filtered off to obtain 40 mg of 1-(2-(4-((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)-2-methylpiperidin-1-yl)ethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one hydrochloride as a light yellow solid.

Provenance & Evidence