Hydrogen chloride-ethyl acetate → 6-{[(1-{2-[7-(methyloxy)-2-oxo-1,5-naphthyridin-1(2H)-yl]ethyl}-4-piperidinyl)amino]methyl}-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one Hydrochloride

Participants

Reaction Steps

To a solution of 260 mg of 1-(2-(4-((3-oxo-3,4-dihydro-2H-pyrido(3,2-b)(1,4)oxazin-6-yl)methylamino)piperidin-1-yl)ethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one in 4 mL of ethyl acetate and 2 mL of methanol, 3 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and the mixture was stirred at room temperature for 12 minutes. The solvent was distilled off under reduced pressure, thereto was added diethyl ether, and the solid was filtered off to obtain 304 mg of 1-(2-(4-((3-oxo-3,4-dihydro-2H-pyrido(3,2-b) (1,4)oxazin-6-yl)methylamino)piperidin-1-yl)ethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one hydrochloride as a white solid.

Provenance & Evidence