反应详情

α-Crystalline form of ivabradine hydrochloride (6 gm) was taken in water (30 ml) and basified by sodium hydroxide solution (50%). Ivabradine, thus formed, was extracted with ethyl acetate (50 ml) and was dried over anhydrous sodium sulfate. Solvent was distilled off. Residue was taken in ethyl acetate (30 ml) and isopropyl alcohol hydrogen chloride (5 ml) was added slowly and was stirred for 2 hours. Product thus obtained was filtered, washed with ethyl acetate (6 ml) and dried at 55-60° C. to obtained amorphous ivabradine hydrochloride having purity 99.93% area by HPLC.