Sodium Hydroxide → Ivabradine

HRID 1510820Notes

Reaction equation

HRID 1510820 reaction equation
[CH3:1][N:2]([CH2:22][C@@H:23]1[C:26]2[CH:27]=[C:28]([O:33][CH3:34])[C:29]([O:31][CH3:32])=[CH:30][C:25]=2[CH2:24]1)[CH2:3][CH2:4][CH2:5][N:6]1[C:16](=[O:17])[CH2:15][C:14]2[C:9](=[CH:10][C:11]([O:20][CH3:21])=[C:12]([O:18][CH3:19])[CH:13]=2)[CH2:8][CH2:7]1.Cl.[OH-].[Na+]>O>[CH3:1][N:2]([CH2:22][C@@H:23]1[C:26]2[CH:27]=[C:28]([O:33][CH3:34])[C:29]([O:31][CH3:32])=[CH:30][C:25]=2[CH2:24]1)[CH2:3][CH2:4][CH2:5][N:6]1[C:16](=[O:17])[CH2:15][C:14]2[C:9](=[CH:10][C:11]([O:20][CH3:21])=[C:12]([O:18][CH3:19])[CH:13]=2)[CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 3045381Ivabradine Hydrochloride

Product 1

HCID 132999Ivabradine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

α-Crystalline form of ivabradine hydrochloride (6 gm) was taken in water (30 ml) and basified by sodium hydroxide solution (50%). Ivabradine, thus formed, was extracted with ethyl acetate (50 ml) and was dried over anhydrous sodium sulfate. Solvent was distilled off. Residue was taken in ethyl acetate (30 ml) and isopropyl alcohol hydrogen chloride (5 ml) was added slowly and was stirred for 2 hours. Product thus obtained was filtered, washed with ethyl acetate (6 ml) and dried at 55-60° C. to obtained amorphous ivabradine hydrochloride having purity 99.93% area by HPLC.

Sources & evidence

ORD record
ord-f67f31a3f8f94eb1b421371d27a3fabd
Source dataset
uspto-grants-2012_07
Patent number
US08212026B2

Reaction notes

Loading…