Sodium Hydroxide → HCID 59757322, compound

Participants

Reaction Steps

A suspension of methyl 3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl](2E)-propenoate (10 g) in ethanol (200 ml) was treated with aqueous sodium hydroxide solution (0.1N, 246 ml) at 0-5° C. The reaction mixture was stirred at 25-30° C. for 12 h for completion of hydrolysis and ethanol was evaporated under reduced pressure. The resulting mass was acidified and extracted with methylene chloride (2×100 ml). The organic layer was washed with water, dried and concentrated to give the title product (Yield 9.4 g).

Provenance & Evidence