Trifluoroacetic acid → HCID 49857170, compound

Participants

Reaction Steps

(S)-tert-Butyl 2-(5-(4-(2-((S)-1-(tert-butoxycarbonyl)-pyrrolidin-2-yl)-1H-imidazol-5-yl)phenyl)-1H-indazol-3-ylcarbamoyl)pyrrolidine-1-carboxylate was deprotected with TFA by the method given in Step 2 of Example 11. Obtained a light yellow solid (183 mg, ca. 73%). 1H NMR (500 MHz, CD3OD) δ 8.16 (s, 1H), 7.88 (app d, J=8.2 Hz, 2H), 7.84 (s, 1H), 7.76-7.79 (m, 3H), 7.59 (d, J=8.9 Hz, 1H), 5.10 (unresolved dd, J=7.9, 8.9 Hz, 1H), 4.63 (unresolved dd, J=7.3, 8.2 Hz, 1H), 3.51-3.62 (m, 3H), 3.43-3.48 (m, 1H), 2.62-2.69 (m, 2H), 2.48-2.55 (m, 1H), 2.15-2.40 (m, 1H). LCMS: Anal. Calcd. for C25H27N7O: 441; found: 442 (M+H)+.

Provenance & Evidence